Fermotein Does Not Exert Genotoxic Effects in Bacterial Reverse Mutation and in Vitro Mammalian Cell Micronucleus Tests

Aim: Fermotein is an innovative single-cell protein obtained from fermentation of the filamentous fungus Rhizomucor pusillus. Like other fungi, a lack information on this species exists to assess its safety for human consumption. The capability induce gene mutations or structural and numerical chromosomal aberrations derived products has never been studied before. objective current study was investigate genotoxic effects using bacterial reverse mutation test in vitro mammalian cell micronucleus test.
 Methodology: were performed accordance with GLP concurrent OECD guidelines. Dose-range finding tests used select appropriate doses Dry. highest genotoxicity experiments determined by solubility mycoprotein.
 Results: Conclusion: No concerns regarding identified no further vivo testing required. Information contributes body evidence novel food authorisation EU GRAS notification US.